TITANIUM DIOXIDE

EU 1223/2009 Annex VI - SCCS opinion: Opinion on Titanium Dioxide

EU 1223/2009 Annex III - SCCS opinion: Titanium dioxide (TiO2) used in cosmetic products that lead to exposure by inhalation.

EU 1223/2009 Annex VI - SCCS opinion: Titanium dioxide (TiO2) used in cosmetic products that lead to exposure by inhalation.

IARC Grup 2B - İnsanlarda kanserojen olması mümkün. Limited evidence in humans and insufficient evidence in experimental animals (or vice versa). (Monograph volume: 47, 93). Sınır: IARC TEHLİKE sınıflandırması yapar, RİSK değil - 'bir koşulda kansere yol açabilir' der, 'kozmetikteki kullanım seviyesinde kanser yapar' DEMEZ. Maruziyet yolu ve dozu ayrıca değerlendirilmelidir. Data is a 01/2021 snapshot.

Cited by 730. Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications. TiO2 NPs possess different physicochemical properties compared to their fine particle (FP) analogs, which might alter their bioactivity. Most of the literature cited here has focused on the respiratory system, showing the importance of inhalation as the primary route

EPA ToxValDB skin/eye data - endpoint: skin sensitisation: in vivo (LLNA), classification: Not likely to be sensitizing, species: mouse, study: skin sensitization, guideline: equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay), year: 2006. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data - endpoint: skin sensitisation: in vivo (non-LLNA), classification: Not likely to be sensitizing, species: guinea pig, study: skin sensitization, guideline: according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) according to EPA OPP 81-6 (Skin Sensitisation), year: 1994. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB genotoxicity: positive - positive reports: 17, negative: 6, Ames: positive, micronucleus: positive. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB kanser değerlendirmesi: 2B - Possibly carcinogenic to humans. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data - endpoint: Eye Irritation, classification: Classification not possible. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.