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SODIUM FLUORIDE

Endocrine8 products
CAS
7681-49-4
EC
2316678
PubChem CID
5235
Molecular Formula
FNa
Molecular Weight
41.9882 g/mol

Sodium fluoride

What does it do?

Provides fluoride ions in the product. Used to strengthen tooth enamel.

Details

Sodium fluoride

a white substance in a black bowl on a beige counter top with the lid down
Ingredient guide

Why is sodium fluoride in toothpaste being debated?

You see "sodium fluoride" on a toothpaste label. The question is simple: is this fluoride harmful or helpful? The ingredient has been used for decades to prevent cavities, but its classification is now being debated in Europe.

Read the full guide →

Function & Use

Oral Care

Antiplaque

Regulatory note

  • EU 1223/2009 Annex IIIRestricted

    Maximum concentration: 0.15%

The verdict isn’t ours: below is what ToxValDB (EPA Toxicity Value Database), SCCS (EU Scientific Committee on Consumer Safety) said, verbatim.

What The Sources Say

SCCS (EU Scientific Committee on Consumer Safety)3
Safety assessment

EU 1223/2009 Annex III - SCCS opinion: Opinion concerning the Safety of Fluorine Compounds in Oral Hygiene Products for Children under the Age of 6 years

Safety assessment

EU 1223/2009 Annex III - SCCS opinion: Opinion on the Safety of Fluorine Compounds in Oral Hygiene Products for Children under the Age of 6 Years

Safety assessment

EU 1223/2009 Annex III - SCCS opinion: Clarification on the Opinions SCCNFP/0653/03 and SCCP/0882/05 on the Safety of Fluorine Compounds in Oral Hygiene Products for Children under the Age of 6 Years

ToxValDB (EPA Toxicity Value Database)10
Hazard claimView source →

EPA ToxValDB skin/eye data - endpoint: Eye Irritation, classification: Eye Irrit. 2. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claimView source →

EPA ToxValDB skin/eye data - endpoint: Skin Irritation, classification: Skin Irrit. 2. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claimView source →

EPA ToxValDB skin/eye data - endpoint: Eye Irritation, classification: Category 1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claimView source →

EPA ToxValDB skin/eye data - endpoint: Skin Sensitization, classification: Classification not possible. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claimView source →

EPA ToxValDB skin/eye data - endpoint: Eye Irritation, classification: Category 6.4A (Category 2A). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

+5 more records.

Scientific References

  • Clarification on the Opinions SCCNFP/0653/03 and SCCP/0882/05 on the Safety of Fluorine Compounds in Oral Hygiene Products for Children under the Age of 6 YearsSCCS - Scientific Committee on Consumer Safety
  • DEDuCT 3.0, Database of Endocrine Disrupting Chemicals and their Toxicity profiles (DEDuCT 3.0)Institute of Mathematical Sciences, Chennai
  • EU Endocrine Disruptor Lists I, II, III (2026-04 update)edlists.org (Danish EPA on behalf of participating EU member states)
  • Opinion concerning the Safety of Fluorine Compounds in Oral Hygiene Products for Children under the Age of 6 yearsSCCS - Scientific Committee on Consumer Safety
  • Opinion on the Safety of Fluorine Compounds in Oral Hygiene Products for Children under the Age of 6 YearsSCCS - Scientific Committee on Consumer Safety

Products Containing This Ingredient