ALPHA-ISOMETHYL IONONE

EU 1223/2009 Annex III - SCCS opinion: Opinion concerning Fragrance Allergy in Consumers - A Review of the Problem - Analysis of the need for appropriate Consumer Information and Identification of Consumer Allergens

EU 1223/2009 Annex III - SCCS opinion: Opinion concerning the Interim Position on Fragrance Allergy

EU 1223/2009 Annex III - SCCS opinion: Memorandum on the SCCNFP Opinion concerning Fragrance Allergy

EU 1223/2009 Annex III - SCCS opinion: Opinion concerning Essential Oils

EPA ToxValDB skin/eye data - endpoint: skin irritation: in vivo, classification: Severe Irritation, species: rat, study: skin irritation, guideline: other guideline: as mentioned below according to, year: 2007. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data - endpoint: skin sensitisation: in vivo (non-LLNA), classification: High Frequency of Sensitization, species: human, study: skin sensitization, guideline: according to other guideline: as mentioned below, year: 2005. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data - endpoint: eye irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: eye irritation, guideline: other guideline: according to, year: 2007. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0.0185, antagonist=0). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.