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Alpha-Isomethyl Ionone

Allergen0 products
CAS
127-51-5
EC
2048463
PubChem CID
61073
Molecular Formula
C14H22O
Molecular Weight
206.3200 g/mol

A component that provides a violet-like scent. Allergen; may cause reactions in sensitive skin.

What does it do?

A fragrance component that provides a violet-like scent and helps soften the skin.

Details

Alpha-Isomethyl Ionone is a synthetic component that gives a violet-like scent; it also helps to soften the skin. Allergen; may cause reactions in sensitive skin. Therefore, it must be specified on the label when used above a certain threshold value in cosmetic products. Those with eczema should be cautious.

Hazards

Allergenⓘ

Benefits

None Specified

Functions

Fragrance

Restrictions

None Specified

Where is it found?

Perfume
Cream
Soap

Function & Use

Skin Conditioning

Perfuming

Skin-Conditioning Agent

Usage Restrictions

  • Maximum Concentration - 3%

    Distributed for Comment Only -- Do Not Cite or Quote

Regulatory note

  • EU 1223/2009 Annex IIIRestricted

Industry GHS notices (PubChem)

These are industry self-reports to ECHA, not our regulatory assessment.

  • H315(100.0%)- Causes skin irritation
  • H317(100.0%)- May cause an allergic skin reaction
  • H319(100.0%)- Causes serious eye irritation
  • H400- Very toxic to aquatic life
  • H410- Very toxic to aquatic life with long lasting effects
  • H411(100.0%)- Toxic to aquatic life with long lasting effects
  • H412(10.2%)- Harmful to aquatic life with long lasting effects
PubChem CID 5372174 →
The verdict isn’t ours: below is what ToxValDB (EPA Toxicity Value Database), SCCS (EU Scientific Committee on Consumer Safety), EPA ToxCast (high-throughput in vitro screening) said, verbatim.

What The Sources Say

SCCS (EU Scientific Committee on Consumer Safety)4
Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Fragrance Allergy in Consumers - A Review of the Problem - Analysis of the need for appropriate Consumer Information and Identification of Consumer Allergens

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion concerning the Interim Position on Fragrance Allergy

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Memorandum on the SCCNFP Opinion concerning Fragrance Allergy

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Essential Oils

ToxValDB (EPA Toxicity Value Database)5
Hazard claimView source →

EPA ToxValDB skin/eye data — endpoint: skin irritation: in vivo, classification: Severe Irritation, species: rat, study: skin irritation, guideline: other guideline: as mentioned below according to, year: 2007. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claimView source →

EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (non-LLNA), classification: High Frequency of Sensitization, species: human, study: skin sensitization, guideline: according to other guideline: as mentioned below, year: 2005. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claimView source →

EPA ToxValDB skin/eye data — endpoint: eye irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: eye irritation, guideline: other guideline: according to, year: 2007. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

+2 more records.

EPA ToxCast (high-throughput in vitro screening)1
Safety assessmentView source →

EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0.0185, antagonist=0). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.

Scientific References

  • CIR — Safety Assessment ofCosmetic Ingredient Review (CIR), Personal Care Products Council(2018)
  • EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
  • EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
  • INCIDB — Skincare & Cosmetics INCI Database (Kaggle 2026.07)INCIDB (derived from EU CosIng, US FDA MoCRA, NLM DailyMed, OBF)
  • Memorandum on the SCCNFP Opinion concerning Fragrance AllergySCCS — Scientific Committee on Consumer Safety
  • OpenFDA Cosmetic Adverse Events (api.fda.gov/cosmetic/event)US FDA — unvalidated adverse event reports
  • Opinion concerning Essential OilsSCCS — Scientific Committee on Consumer Safety
  • Opinion concerning Fragrance Allergy in Consumers - A Review of the Problem - Analysis of the need for appropriate Consumer Information and Identification of Consumer AllergensSCCS — Scientific Committee on Consumer Safety
  • Opinion concerning the Interim Position on Fragrance AllergySCCS — Scientific Committee on Consumer Safety
  • PubChem — CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
  • ToxCast ER model — alpha-Isomethylionone (DTXSID7027047)US EPA — ToxCast / CompTox
  • ToxValDB — genotoxicityUS EPA — ToxValDB v97
  • ToxValDB — skin/eyeUS EPA — ToxValDB v97