ACID BLUE 9

EU 1223/2009 Annex III - SCCS opinion: Opinion on Acid Blue 9

IARC Grup 3 - Kanserojenliği sınıflandırılamıyor. The available evidence is insufficient for a classification. This does NOT mean 'safe'; it means 'not enough data'. (Monograph volume: 16, Sup 7). Sınır: IARC TEHLİKE sınıflandırması yapar, RİSK değil - 'bir koşulda kansere yol açabilir' der, 'kozmetikteki kullanım seviyesinde kanser yapar' DEMEZ. Maruziyet yolu ve dozu ayrıca değerlendirilmelidir. Data is a 01/2021 snapshot.

EPA ToxValDB skin/eye data - endpoint: skin sensitisation: in vivo (LLNA), classification: Not likely to be sensitizing, species: mouse, study: skin sensitization, guideline: equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay), year: 2004. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data - endpoint: eye irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: eye irritation, guideline: OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to, year: 1982. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data - endpoint: skin irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: skin irritation, guideline: OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to, year: 1982. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB genotoxicity: positive - positive reports: 14, negative: 6, Ames: positive, micronucleus: positive. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB kanser değerlendirmesi: 3 - Not classifiable as to its carcinogenicity to humans. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0, antagonist=0.000382). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.