Triclocarban
- CAS
- 101-20-2
- EC
- 202-924-1
- PubChem CID
- 7547
- Molecular Formula
- C13H9Cl3N2O
- Molecular Weight
- 315.6000 g/mol
Antibacterial chemical. Use is restricted as it interferes with hormonal balance and is harmful to the environment.
What does it do?
An antibacterial component.
Details
Triclocarban is a synthetic substance providing antibacterial effects in soaps and cleansers. Due to its potential to disrupt the endocrine system and harm the environment, its use is restricted; it may only be present in rinse-off products at a maximum concentration of 1.5%.
Hazards
Benefits
Functions
Restrictions
Where is it found?
Also known as
Function & Use
Preservative
Deodorant
Usage Restrictions
- Maximum Concentration - 0.2%
SCCS maximum concentration; safe: up to 0.3% (SCCS/1643/22)
- Rinse-off Maximum - 1.5%
rinse-off products
- Use Condition - 100MoS
Margin of Safety — MoS is < 100
- Use Condition - 40µg/kg bw/day
sed as the PoD (LOAEL = 40 mg/kg bw/day
Regulatory note
- EU 1223/2009 Annex IIIRestricted
Maximum concentration: 1.5%
- EU 1223/2009 Annex VAllowed
Maximum concentration: 0.2%
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H400(96.8%)- Very toxic to aquatic life
- H410(100.0%)- Very toxic to aquatic life with long lasting effects
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)4
EU 1223/2009 Annex V — SCCS opinion: Opinion on Triclocarban - For other uses than as a preservative
EU 1223/2009 Annex V — SCCS opinion: Request for a scientific advice on the safety of triclocarban and triclosan as substances with potential endocrine disrupting properties
EU 1223/2009 Annex III — SCCS opinion: Opinion on Triclocarban - For other uses than as a preservative
EU 1223/2009 Annex V — SCCS opinion: Opinion concerning Restrictions on Materials listed in annex VI of Directive 76/768/EEC on Cosmetic Products
Europe PMC (scientific literature)1
Cited by 180. The topical antiseptic agent triclocarban (TCC) is a common additive in many antimicrobial household consumables, including soaps and other personal care products. Long-term usage of the mass-produced compound and a lack of understanding of its fate during sewage treatment motivated the present mass balance analysis conducted at a typical U.S. activated sludge wastewater treatment plant featuring
ToxValDB (EPA Toxicity Value Database)5
EPA ToxValDB skin/eye data — endpoint: skin irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: guinea pig, study: skin irritation, guideline: other guideline: according to, year: 2011. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (non-LLNA), classification: Not likely to be sensitizing, species: human, study: skin sensitization, guideline: according to other guideline:, year: 1978. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: eye irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: eye irritation, guideline: OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to, year: 2013. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: eye irritation: in vivo, classification: Moderate or Mild Irritation, species: rabbit, study: eye irritation, guideline: other guideline: as below according to, year: 2005. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+1 more records.
EPA ToxCast (high-throughput in vitro screening)1
EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0, antagonist=0.000479). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.
Scientific References
- EPA CompTox Chemicals Dashboard - DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EPA ToxCast/Tox21 - endocrine pathway screening (ER CERAPP, AR)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng - Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- Opinion concerning Restrictions on Materials listed in annex VI of Directive 76/768/EEC on Cosmetic ProductsSCCS — Scientific Committee on Consumer Safety
- Opinion on Triclocarban - For other uses than as a preservativeSCCS — Scientific Committee on Consumer Safety
- Partitioning, persistence, and accumulation in digested sludge of the topical antiseptic triclocarban during wastewater treatment.Environmental science & technology
- PubChem - CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
- Request for a scientific advice on the safety of triclocarban and triclosan as substances with potential endocrine disrupting propertiesSCCS — Scientific Committee on Consumer Safety
- SCCS Opinion SCCS/1643/22 - Safety of Triclocarban and Triclosan as substances with potential endocrine disrupting properties in cosmetic productsScientific Committee on Consumer Safety (SCCS)(2022)
- ToxCast ER model - Triclocarban (DTXSID4026214)US EPA — ToxCast / CompTox
- ToxValDB - genotoxicityUS EPA — ToxValDB v97
- ToxValDB - skin/eyeUS EPA — ToxValDB v97