STYRENE OXIDE
- CAS
- 96-09-3
- EC
- 2024767
- PubChem CID
- 7276
- Molecular Formula
- C8H8O
- Molecular Weight
- 120.1500 g/mol
A full English write-up is not available yet. Category and regulatory notes above still apply.
Benefits
Functions
Restrictions
Function & Use
Not Reported
Regulatory note
- EU 1223/2009 Annex IIProhibited
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H227- Combustible liquid
- H302- Harmful if swallowed
- H311(15.0%)- Toxic in contact with skin
- H312(80.7%)- Harmful in contact with skin
- H315(57.2%)- Causes skin irritation
- H317(57.0%)- May cause an allergic skin reaction
- H319(95.7%)- Causes serious eye irritation
- H331(57.0%)- Toxic if inhaled
- H332- Harmful if inhaled
- H336- May cause drowsiness or dizziness
- H340(42.2%)- May cause genetic defects
- H341(25.1%)- Suspected of causing genetic defects
- H350(95.7%)- May cause cancer
- H361- Suspected of damaging fertility or the unborn child
- H370- Causes damage to organs
- H401- Toxic to aquatic life
- H412- Harmful to aquatic life with long lasting effects
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)4
EU 1223/2009 Annex II — SCCS opinion: Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EECC
EU 1223/2009 Annex II — SCCS opinion: Opinion concerning Chemical Ingredients in Cosmetic Products classified as Carcinogenic
EU 1223/2009 Annex II — SCCS opinion: Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EEC
+1 more records.
IARC (International Agency for Research on Cancer)1
IARC Group 2A - Probably carcinogenic to humans. Limited evidence in humans, sufficient evidence in experimental animals. (Monograph volume: Sup 7, 60, 121). Caveat: IARC classifies HAZARD, not RISK - it says 'can cause cancer under some conditions', not 'causes cancer at cosmetic use levels'. Route and dose must be assessed separately. Data is a 01/2021 snapshot.
ToxValDB (EPA Toxicity Value Database)10
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Category 1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Category 6.4A (Category 2A). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: eye irritation: in vivo, classification: Severe Irritation, species: rabbit, study: eye irritation, guideline: OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to, year: 1990. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB kanser değerlendirmesi: 2A - Probably carcinogenic to humans. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB genotoxicity: positive — positive reports: 36, negative: 14, Ames: positive, micronucleus: positive. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+5 more records.
EPA ToxCast (high-throughput in vitro screening)1
EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0, antagonist=0). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.
Scientific References
- EPA CompTox Chemicals Dashboard - DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng - Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- IARC Monographs - Styrene oxide (Group 2A - Probably carcinogenic to humans)IARC — WHO Uluslararası Kanser Araştırmaları Ajansı
- Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EECSCCS — Scientific Committee on Consumer Safety
- Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EECCSCCS — Scientific Committee on Consumer Safety
- Opinion concerning Chemical Ingredients in Cosmetic Products classified as CarcinogenicSCCS — Scientific Committee on Consumer Safety
- PubChem - CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
- ToxCast ER model - Styrene oxide (DTXSID2021286)US EPA — ToxCast / CompTox
- ToxValDB - cancerUS EPA — ToxValDB v97
- ToxValDB - genotoxicityUS EPA — ToxValDB v97
- ToxValDB - skin/eyeUS EPA — ToxValDB v97