P-PHENYLENEDIAMINE
- CAS
- 106-50-3
- PubChem CID
- 7814
- Molecular Formula
- C6H8N2
- Molecular Weight
- 108.1400 g/mol
A full English write-up is not available yet. Category and regulatory notes above still apply.
Hazards
Benefits
Functions
Restrictions
Function & Use
Hair Dyeing
Regulatory note
- EU 1223/2009 Annex IIIRestricted
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H301(99.7%)- Toxic if swallowed
- H311(99.7%)- Toxic in contact with skin
- H315- Causes skin irritation
- H317(99.8%)- May cause an allergic skin reaction
- H318- Causes serious eye damage
- H319(99.7%)- Causes serious eye irritation
- H320- Causes eye irritation
- H331(99.7%)- Toxic if inhaled
- H333- H333
- H334- May cause allergy or asthma symptoms or breathing difficulties if inhaled
- H370(38.9%)- Causes damage to organs
- H400(98.3%)- Very toxic to aquatic life
- H410(99.7%)- Very toxic to aquatic life with long lasting effects
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)4
EU 1223/2009 Annex III — SCCS opinion: Opinion on p-Phenylenediamine
EU 1223/2009 Annex III — SCCS opinion: Memorandum on Hair Dye Substances and their Skin Sensitising Properties
EU 1223/2009 Annex III — SCCS opinion: Opinion on reaction products of oxidative hair dye ingredients formed during hair dyeing processes
EU 1223/2009 Annex III — SCCS opinion: Opinion concerning p-Phenylenediamine
IARC (International Agency for Research on Cancer)1
IARC Group 3 - Not classifiable as to carcinogenicity. The available evidence is insufficient for a classification. This does NOT mean 'safe'; it means 'not enough data'. (Monograph volume: 16, Sup 7). Caveat: IARC classifies HAZARD, not RISK - it says 'can cause cancer under some conditions', not 'causes cancer at cosmetic use levels'. Route and dose must be assessed separately. Data is a 01/2021 snapshot.
ToxValDB (EPA Toxicity Value Database)16
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Category 1A. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Category 6.4A (Category 2A). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Category 6.5B (Category 1). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: guinea pig, study: skin irritation, guideline: other guideline: EPA OPP 81-6 (Skin Sensitization) according to, year: 1987. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (LLNA), classification: High Frequency of Sensitization, species: mouse, study: skin sensitization, guideline: equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay), year: 1999. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+11 more records.
EPA ToxCast (high-throughput in vitro screening)1
EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0.0201, antagonist=0.0158). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.
Scientific References
- EPA CompTox Chemicals Dashboard - DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng - Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- IARC Monographs - 1,4-Benzenediamine (Group 3 - Not classifiable as to carcinogenicity)IARC — WHO Uluslararası Kanser Araştırmaları Ajansı
- Memorandum on Hair Dye Substances and their Skin Sensitising PropertiesSCCS — Scientific Committee on Consumer Safety
- Opinion concerning p-PhenylenediamineSCCS — Scientific Committee on Consumer Safety
- Opinion on p-PhenylenediamineSCCS — Scientific Committee on Consumer Safety
- Opinion on reaction products of oxidative hair dye ingredients formed during hair dyeing processesSCCS — Scientific Committee on Consumer Safety
- PubChem - CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
- ToxCast ER model - 1,4-Benzenediamine (DTXSID9021138)US EPA — ToxCast / CompTox
- ToxValDB - cancerUS EPA — ToxValDB v97
- ToxValDB - genotoxicityUS EPA — ToxValDB v97
- ToxValDB - skin/eyeUS EPA — ToxValDB v97