Musk xylene
- CAS
- 81-15-2
- EC
- 2013294
- PubChem CID
- 62329
- Molecular Formula
- C12H15N3O6
- Molecular Weight
- 297.2600 g/mol
Fragrance fixative in perfumes. May accumulate in the body and can be harmful to the environment; its use is restricted.
What does it do?
Used as a fragrance fixative in perfumes.
Details
A synthetic substance used as a fragrance fixative in perfumes. Due to its tendency to accumulate in the body and its harmful effects on the environment, its use is restricted. Products containing this substance must not exceed specific concentrations.
Hazards
Benefits
Functions
Restrictions
Where is it found?
Also known as
Function & Use
Perfuming
Masking
Regulatory note
- EU 1223/2009 Annex IIIRestricted
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H201(100.0%)- H201
- H228- Flammable solid
- H320- Causes eye irritation
- H351(100.0%)- Suspected of causing cancer
- H400(100.0%)- Very toxic to aquatic life
- H410(100.0%)- Very toxic to aquatic life with long lasting effects
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)3
EU 1223/2009 Annex III — SCCS opinion: Opinion on Musk ketone and Musk xylene
EU 1223/2009 Annex III — SCCS opinion: Opinion on Musk xylene
+1 more records.
IARC (International Agency for Research on Cancer)1
IARC Group 3 - Not classifiable as to carcinogenicity. The available evidence is insufficient for a classification. This does NOT mean 'safe'; it means 'not enough data'. (Monograph volume: 65). Caveat: IARC classifies HAZARD, not RISK - it says 'can cause cancer under some conditions', not 'causes cancer at cosmetic use levels'. Route and dose must be assessed separately. Data is a 01/2021 snapshot.
Europe PMC (scientific literature)1
Cited by 64. Nitro benzenoid musk compounds (Musk tibetene [CAS no. 145-39-1], Musk ambrette [83-66-9], Musk moskene [116-66-5], Musk ketone [81-14-1] and Musk xylene [81-15-2]) and non-nitro benzenoid musks (Celestolide [13171-00-1], Galaxolide [1222-05-5]) and Fixolide [1506-02-1] [21445-77-7] were analysed in 15 human adipose tissue samples from Switzerland by gas chromatography/high resolution mass spectro
ToxValDB (EPA Toxicity Value Database)4
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Category 2B. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Classification not possible. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Not classified. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB kanser değerlendirmesi: 3 - Not classifiable as to its carcinogenicity to humans. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
Scientific References
- EPA CompTox Chemicals Dashboard - DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng - Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- IARC Monographs - 2,4,6-Trinitro-1,3-dimethyl-5-tert-butylbenzene (Group 3 - Not classifiable as to carcinogenicity)IARC — WHO Uluslararası Kanser Araştırmaları Ajansı
- Occurrence of nitro and non-nitro benzenoid musk compounds in human adipose tissue.Chemosphere
- Opinion on Musk ketone and Musk xyleneSCCS — Scientific Committee on Consumer Safety
- Opinion on Musk xyleneSCCS — Scientific Committee on Consumer Safety
- ToxValDB - cancerUS EPA — ToxValDB v97
- ToxValDB - skin/eyeUS EPA — ToxValDB v97