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Daidzein

Controversial0 products
CAS
486-66-8
EC
2076354
PubChem CID
5281708
Molecular Formula
C15H10O4
Molecular Weight
254.2400 g/mol

Skin-nourishing antioxidant. May interfere with hormonal regulation; EU limit is 0.02%.

What does it do?

An antioxidant that nourishes the skin and protects it against external factors.

Details

A soy-derived isoflavone like Genistein, acting as an antioxidant and nourishing agent for the skin. It has the potential to interfere with hormonal regulation. The EU does not permit use in cosmetics at concentrations higher than 0.02%.

Hazards

Endocrine Disruptorⓘ

Benefits

Antioxidantⓘ

Functions

Active Ingredient

Restrictions

None Specified

Where is it found?

Skin care serum
Face cream

Also known as

Daidzeol; 4',7-Dihydroxyisoflavone; 7-hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone

Function & Use

Skin Conditioning

Regulatory note

  • EU 1223/2009 Annex IIIRestricted

    Maximum concentration: 0.02%

Industry GHS notices (PubChem)

These are industry self-reports to ECHA, not our regulatory assessment.

  • H315(95.1%)- Causes skin irritation
  • H319(95.1%)- Causes serious eye irritation
PubChem CID 5281708 →
The verdict isn’t ours: below is what SCCS (EU Scientific Committee on Consumer Safety), EPA ToxCast (high-throughput in vitro screening) said, verbatim.

What The Sources Say

SCCS (EU Scientific Committee on Consumer Safety)5
Safety assessment

EU 1223/2009 Annex III — SCCS opinion: preliminary version of 12 January 2022

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: final version of 16 September 2022

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Scientific opinion on genistein and daidzein

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: SCCS/1641/22

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: corrigendum of 11 October 2022

EPA ToxCast (high-throughput in vitro screening)1
Hazard claimView source →

EPA ToxCast ER model: estrogen receptor AGONIST (AUC agonist=0.44). Model call derived from 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.

Scientific References

  • corrigendum of 11 October 2022SCCS — Scientific Committee on Consumer Safety
  • EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
  • EPA ToxCast/Tox21 — endocrine pathway screening (ER CERAPP, AR)US EPA, Center for Computational Toxicology and Exposure
  • EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
  • final version of 16 September 2022SCCS — Scientific Committee on Consumer Safety
  • preliminary version of 12 January 2022SCCS — Scientific Committee on Consumer Safety
  • SCCS/1641/22SCCS — Scientific Committee on Consumer Safety
  • Scientific opinion on genistein and daidzeinSCCS — Scientific Committee on Consumer Safety
  • ToxCast ER model — Daidzein (DTXSID9022310)US EPA — ToxCast / CompTox
  • ToxValDB — genotoxicityUS EPA — ToxValDB v97