ACRYLAMIDE
- CAS
- 79-06-1
- EC
- 2011737
- PubChem CID
- 6579
- Molecular Formula
- C3H5NO
- Molecular Weight
- 71.0800 g/mol
A full English write-up is not available yet. Category and regulatory notes above still apply.
Hazards
Benefits
Functions
Restrictions
Function & Use
Not Reported
Regulatory note
- EU 1223/2009 Annex IIProhibited
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H301(94.8%)- Toxic if swallowed
- H311- Toxic in contact with skin
- H312(94.2%)- Harmful in contact with skin
- H315(96.2%)- Causes skin irritation
- H316- H316
- H317(96.2%)- May cause an allergic skin reaction
- H319(96.0%)- Causes serious eye irritation
- H332(94.6%)- Harmful if inhaled
- H340(96.2%)- May cause genetic defects
- H350(96.1%)- May cause cancer
- H360- May damage fertility or the unborn child
- H361(94.1%)- Suspected of damaging fertility or the unborn child
- H370- Causes damage to organs
- H372(94.8%)- Causes damage to organs through prolonged or repeated exposure
- H402- Harmful to aquatic life
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)4
EU 1223/2009 Annex II — SCCS opinion: Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EEC
EU 1223/2009 Annex II — SCCS opinion: Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EECC
EU 1223/2009 Annex II — SCCS opinion: Opinion concerning Chemical Ingredients in Cosmetic Products classified as Carcinogenic
+1 more records.
IARC (International Agency for Research on Cancer)1
IARC Group 2A - Probably carcinogenic to humans. Limited evidence in humans, sufficient evidence in experimental animals. (Monograph volume: 60, Sup 7). Caveat: IARC classifies HAZARD, not RISK - it says 'can cause cancer under some conditions', not 'causes cancer at cosmetic use levels'. Route and dose must be assessed separately. Data is a 01/2021 snapshot.
ToxValDB (EPA Toxicity Value Database)23
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Skin irritation - category 2. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Skin sensitisation - category 1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Serious eye damage/eye irritation - Category 2. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Not classified. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Category 6.3B (Category 3). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+18 more records.
EPA ToxCast (high-throughput in vitro screening)1
EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0, antagonist=0). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.
Scientific References
- EPA CompTox Chemicals Dashboard - DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EPA ToxCast/Tox21 - endocrine pathway screening (ER CERAPP, AR)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng - Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- IARC Monographs - Acrylamide (Group 2A - Probably carcinogenic to humans)IARC — WHO Uluslararası Kanser Araştırmaları Ajansı
- Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EECSCCS — Scientific Committee on Consumer Safety
- Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EECCSCCS — Scientific Committee on Consumer Safety
- Opinion concerning Chemical Ingredients in Cosmetic Products classified as CarcinogenicSCCS — Scientific Committee on Consumer Safety
- PubChem - CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
- ToxCast ER model - Acrylamide (DTXSID5020027)US EPA — ToxCast / CompTox
- ToxValDB - cancerUS EPA — ToxValDB v97
- ToxValDB - genotoxicityUS EPA — ToxValDB v97
- ToxValDB - skin/eyeUS EPA — ToxValDB v97