5-Amino-6-Chloro-o-Cresol

Definition and Structure According to the Dictionary, 6-Amino-o-Cresol (CAS No. 17672-22-9) is the substituted aromatic compound that conforms to formula in Figure 1.1 However, the use of regiochemical terms such as “ortho-” (i.e., the “-o-” in 6-Amino-o- Cresol) is vague and inappropriate when an aromatic system such as a benzene ring has more than 2 substituents. Thus, a technical name, such as 2-amino-6-methylphenol, is more common in the literature. Figure 1. 6-Amino-o-Cresol 6-Amino-o-Cresol is used as a coupler in oxidative hair dye systems. Couplers, sometimes referred to as color modifiers, react with oxidized hair dye ingredients referred to as precursors. Couplers can react with 2 equivalents of precursor (to form a sort of trimer), or if “blocked” react with 1 equivalent of precursor (to form a sort of dimer). The methyl group on 6-Amino-o-Cresol actively blocks one of those position; thus, this ingredient reacts with precursors to only form dimer like products (Figure 2). Figure 2. An example (with p-Phenylenediamine, in this case) of the oxidative coupling reaction of 6-Amino-o-Cresol  Distributed for Comment Only -- Do Not Cite or Quote Chemical Properties 6-Amino-o-Cresol has the molecular weight of 123.07 Daltons (Da).2 No further chemical properties data were found. Method of Manufacture Method of manufacturing data for 6-Amino-o-Cresol were not included in the original report and were not found in the updated literature search, and unpublished data were not submitted. Impurities Composition and impurities data of 6-Amino-o-Cresol were not included in the original report and were not found in the updated literature search, and unpublished data were not submitted. … [kırpıldı — bölüm toplam 5458 karakter]

Ocular irritation studies of 6-Amino-o-Cresol were not included in the original report and were not found in the updated literature search, and unpublished data were not submitted. HAIR DYE EPIDEMIOLOGY Hair dyes may be broadly grouped into oxidative (permanent) and direct (temporary or semi-permanent) dyes. The oxidative dyes consist of precursors mixed with developers to produce color, while direct hair dyes consist of preformed colors. 6-Amino-o-Cresol is reported to be used in semi-permanent and oxidative hair dye formulations. While the safety of individual hair dye ingredients is not addressed in epidemiology studies that seek to determine links, if any, between hair dye use and disease, such studies do provide broad information. The Panel determined that the available hair dye epidemiology data do not provide sufficient evidence for a causal relationship between personal hair dye use and cancer. A detailed summary of the available hair dye epidemiology data is available at https://www.cir-safety.org/cir-findings.

Dermal irritation and sensitization studies of 6-Amino-o-Cresol were not included in the original report and were not found in the updated literature search, and unpublished data were not submitted.

Carcinogenicity studies of 6-Amino-o-Cresol were not included in the original report and were not found in the updated literature search, and unpublished data were not submitted.

Genotoxicity studies of 6-Amino-o-Cresol were not included in the original report and were not found in the updated literature search, and unpublished data were not submitted.

EPA ToxValDB skin/eye data — endpoint: eye irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: eye irritation, guideline: OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to, year: 2003. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: skin irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: skin irritation, guideline: OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EPA OPPTS 870.2500 (Acute Dermal Irritation) according to, year: 2003. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (LLNA), classification: Not likely to be sensitizing, species: mouse, study: skin sensitization, guideline: according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation), year: 2004. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.