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4-Nitrophenyl aminoethylurea

Controversial0 products
CAS
27080-42-8
EC
4107001
PubChem CID
7342344
Molecular Formula
C9H12N4O3
Molecular Weight
224.2200 g/mol

Colorant in hair dyes. Should be used with caution due to allergenic properties; permitted in limited amounts.

What does it do?

Used as a colorant in hair dyes.

Details

A synthetic hair dye that creates color tones from yellow to orange. It may cause allergic reactions upon skin contact; redness, itching, and swelling may be observed in sensitive individuals. It is important to prevent the product from touching the skin during dyeing. Labels may include terms such as 'Nitrophenyl' or 'urea-based dye'.

Hazards

Carcinogenicⓘ
Target Organ Toxic

Benefits

None Specified

Functions

Colorant

Restrictions

Risky During Pregnancy

Where is it found?

Hair dyes

Also known as

1-(beta-Ureidoethyl)amino-4-nitrobenzene

Function & Use

Hair Dyeing

Regulatory note

  • EU 1223/2009 Annex IIIRestricted

Industry GHS notices (PubChem)

These are industry self-reports to ECHA, not our regulatory assessment.

  • H317(100.0%)- May cause an allergic skin reaction
  • H412(100.0%)- Harmful to aquatic life with long lasting effects
PubChem CID 7342344 →
The verdict isn’t ours: below is what SCCS (EU Scientific Committee on Consumer Safety), ToxValDB (EPA Toxicity Value Database) said, verbatim.

What The Sources Say

SCCS (EU Scientific Committee on Consumer Safety)8
Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic Products

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion on Personal Use of Hair Dyes and Cancer Risk

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Assessment Strategies for Hair Dyes

+3 more records.

ToxValDB (EPA Toxicity Value Database)2
Hazard claimView source →

EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Skin Sens. 1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

+1 more records.

Scientific References

  • Assessment Strategies for Hair DyesSCCS — Scientific Committee on Consumer Safety
  • EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
  • EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
  • Memorandum on Hair Dye Substances and their Skin Sensitising PropertiesSCCS — Scientific Committee on Consumer Safety
  • Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004SCCS — Scientific Committee on Consumer Safety
  • Opinion on 4-Nitrophenyl aminoethylureaSCCS — Scientific Committee on Consumer Safety
  • Opinion on Personal Use of Hair Dyes and Cancer RiskSCCS — Scientific Committee on Consumer Safety
  • Opinion on the Use of Permanent Hair Dyes and Bladder Cancer RiskSCCS — Scientific Committee on Consumer Safety
  • PubChem — CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
  • Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic ProductsSCCS — Scientific Committee on Consumer Safety
  • ToxValDB — genotoxicityUS EPA — ToxValDB v97
  • ToxValDB — skin/eyeUS EPA — ToxValDB v97