4-Hydroxypropylamino-3-nitrophenol
- CAS
- 92952-81-3
- EC
- 4063059
- PubChem CID
- 5463795
- Molecular Formula
- C9H12N2O4
- Molecular Weight
- 212.2000 g/mol
Colorant in hair dye. May cause skin allergy and irritation; use is restricted.
What does it do?
Used as a colorant in hair dyes.
Details
A synthetic hair dye colorant used to provide color in both permanent and temporary hair dyes. Its use is limited to certain ratios because of its potential to cause skin allergy and irritation. People with sensitivity to hair dyes or eczema should be particularly careful.
Hazards
Benefits
Functions
Restrictions
Where is it found?
Also known as
Function & Use
Hair Dyeing
Regulatory note
- EU 1223/2009 Annex IIIRestricted
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H315(100.0%)- Causes skin irritation
- H411(100.0%)- Toxic to aquatic life with long lasting effects
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)8
EU 1223/2009 Annex III — SCCS opinion: Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic Products
EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004
EU 1223/2009 Annex III — SCCS opinion: Opinion on Personal Use of Hair Dyes and Cancer Risk
EU 1223/2009 Annex III — SCCS opinion: Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk
EU 1223/2009 Annex III — SCCS opinion: Assessment Strategies for Hair Dyes
+3 more records.
ToxValDB (EPA Toxicity Value Database)4
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Skin Irrit. 2. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (non-LLNA), classification: Not likely to be sensitizing, species: guinea pig, study: skin sensitization, guideline: according to other guideline: 84/449/EWG, B.6 (Meerschweinchen-Maximierungstest (GPMT)); OECD 406, year: 1991. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: eye irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: eye irritation, guideline: other guideline: 84/449/EWG, B.5 according to, year: 1991. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin irritation: in vivo, classification: Severe Irritation, species: rabbit, study: skin irritation, guideline: other guideline: 84/449/EWG, B.4; OECD 404 according to, year: 1991. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
Scientific References
- Assessment Strategies for Hair DyesSCCS — Scientific Committee on Consumer Safety
- EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- Memorandum on Hair Dye Substances and their Skin Sensitising PropertiesSCCS — Scientific Committee on Consumer Safety
- Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004SCCS — Scientific Committee on Consumer Safety
- Opinion on 4-Hydroxypropylamino-3-nitrophenolSCCS — Scientific Committee on Consumer Safety
- Opinion on Personal Use of Hair Dyes and Cancer RiskSCCS — Scientific Committee on Consumer Safety
- Opinion on the Use of Permanent Hair Dyes and Bladder Cancer RiskSCCS — Scientific Committee on Consumer Safety
- PubChem — CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
- Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic ProductsSCCS — Scientific Committee on Consumer Safety
- ToxValDB — skin/eyeUS EPA — ToxValDB v97