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3-Nitro-p-hydroxyethylaminophenol

Controversial0 products
CAS
65235-31-6
EC
2656480
PubChem CID
5488102
Molecular Formula
C8H10N2O4
Molecular Weight
198.1800 g/mol

Colorant in hair dyes. May cause skin irritation and allergies; use is restricted.

What does it do?

Used as a colorant in hair dyes.

Details

This synthetic dye chemical is used as a colorant in hair dyes, providing shades from yellow to orange. It can cause irritation upon skin contact and lead to allergic reactions in some individuals. Gloves should be used during the dyeing process to prevent skin contact. It may appear on product labels as '3-Nitro' or in abbreviated forms.

Hazards

Irritantⓘ
Allergenⓘ

Benefits

None Specified

Functions

Active Ingredient
Colorant

Restrictions

Risky During Pregnancy
Not Suitable for Infants
Risky While Breastfeeding

Where is it found?

Hair dyes

Also known as

4-[(2-Hydroxyethyl)amino]-3-nitrophenol

Function & Use

Hair Dyeing

Regulatory note

  • EU 1223/2009 Annex IIIRestricted

Industry GHS notices (PubChem)

These are industry self-reports to ECHA, not our regulatory assessment.

  • H302(33.8%)- Harmful if swallowed
  • H315(96.1%)- Causes skin irritation
  • H317(83.1%)- May cause an allergic skin reaction
  • H319(45.5%)- Causes serious eye irritation
  • H335(15.6%)- May cause respiratory irritation
  • H411(80.5%)- Toxic to aquatic life with long lasting effects
PubChem CID 5488102 →
The verdict isn’t ours: below is what SCCS (EU Scientific Committee on Consumer Safety) said, verbatim.

What The Sources Say

SCCS (EU Scientific Committee on Consumer Safety)7
Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic Products

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion on Personal Use of Hair Dyes and Cancer Risk

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Assessment Strategies for Hair Dyes

+2 more records.

Scientific References

  • Assessment Strategies for Hair DyesSCCS — Scientific Committee on Consumer Safety
  • EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
  • EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
  • Memorandum on Hair Dye Substances and their Skin Sensitising PropertiesSCCS — Scientific Committee on Consumer Safety
  • Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004SCCS — Scientific Committee on Consumer Safety
  • Opinion on 3-Nitro-p-hydroxyethylaminophenolSCCS — Scientific Committee on Consumer Safety
  • Opinion on Personal Use of Hair Dyes and Cancer RiskSCCS — Scientific Committee on Consumer Safety
  • Opinion on the Use of Permanent Hair Dyes and Bladder Cancer RiskSCCS — Scientific Committee on Consumer Safety
  • PubChem — CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
  • Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic ProductsSCCS — Scientific Committee on Consumer Safety