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2-Hydroxyethylamino-5-nitroanisole

Controversial0 products
CAS
66095-81-6
EC
2661380
PubChem CID
3017645
Molecular Formula
C9H12N2O4
Molecular Weight
212.2000 g/mol

Colorant in hair dyes. Carries a risk of allergic reactions; use is restricted.

What does it do?

Used as a colorant in hair dyes.

Details

A synthetic dye used as an active coloring agent in hair dyes. It imparts yellowish-orange tones to the product. Because it contains a nitro group, allergic reactions may occur on the skin, especially around the eyes and on the scalp. Individuals with allergies or sensitive skin should be cautious when using dyes containing this substance. It may appear on labels as 'HC Yellow 7' or simply 'nitro dye'.

Hazards

Irritantⓘ
Toxic
Target Organ Toxic

Benefits

None Specified

Functions

Colorant

Restrictions

Risky During Pregnancy
Not Suitable for Infants

Where is it found?

Hair dyes

Also known as

2-[(2-methoxy-4-nitrophenyl)amino]ethanol and its salts

Function & Use

Hair Dyeing

Regulatory note

  • EU 1223/2009 Annex IIIRestricted

    Maximum concentration: 0.2%

Industry GHS notices (PubChem)

These are industry self-reports to ECHA, not our regulatory assessment.

  • H302(100.0%)- Harmful if swallowed
  • H315(14.3%)- Causes skin irritation
  • H319(14.3%)- Causes serious eye irritation
  • H335(14.3%)- May cause respiratory irritation
PubChem CID 3017645 →
The verdict isn’t ours: below is what SCCS (EU Scientific Committee on Consumer Safety) said, verbatim.

What The Sources Say

SCCS (EU Scientific Committee on Consumer Safety)9
Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic Products

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion on Personal Use of Hair Dyes and Cancer Risk

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Assessment Strategies for Hair Dyes

+4 more records.

Scientific References

  • Assessment Strategies for Hair DyesSCCS — Scientific Committee on Consumer Safety
  • EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
  • EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
  • Memorandum on Hair Dye Substances and their Skin Sensitising PropertiesSCCS — Scientific Committee on Consumer Safety
  • Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004SCCS — Scientific Committee on Consumer Safety
  • Opinion on 2-Hydroxyethylamino-5-nitroanisoleSCCS — Scientific Committee on Consumer Safety
  • Opinion on Personal Use of Hair Dyes and Cancer RiskSCCS — Scientific Committee on Consumer Safety
  • Opinion on the Use of Permanent Hair Dyes and Bladder Cancer RiskSCCS — Scientific Committee on Consumer Safety
  • PubChem — CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
  • Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic ProductsSCCS — Scientific Committee on Consumer Safety
  • ToxValDB — genotoxicityUS EPA — ToxValDB v97