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2-Chloro-6-ethylamino-4-nitrophenol

Controversial0 products
CAS
131657-78-8
EC
4114401
PubChem CID
9794399
Molecular Formula
C8H9ClN2O3
Molecular Weight
216.6200 g/mol

A chemical that provides yellow-orange tones in hair dyes. Used in oxidative and non-oxidative dyes; its use is restricted and it may cause allergies.

What does it do?

A component that enables the creation of yellow to orange color tones in hair dyes.

Details

A synthetic substance used to create warm tones ranging from yellow to orange in hair dyes. It may be present in both permanent and temporary hair dye formulations. Its use in temporary dyes is limited to 3%. Like other similar dyes, it has the potential to cause allergies, so those with sensitive scalps should be careful.

Hazards

None Specified

Benefits

None Specified

Functions

Colorant

Restrictions

None Specified

Where is it found?

Oxidative hair dyes
Non-oxidative hair dyes

Also known as

Phenol, 2-Chloro-6-(ethylamino)-4-nitro-

Function & Use

Hair Dyeing

Regulatory note

  • EU 1223/2009 Annex IIIRestricted

    Maximum concentration: 3%

Industry GHS notices (PubChem)

These are industry self-reports to ECHA, not our regulatory assessment.

  • H302(100.0%)- Harmful if swallowed
  • H317(100.0%)- May cause an allergic skin reaction
  • H411(100.0%)- Toxic to aquatic life with long lasting effects
PubChem CID 9794399 →
The verdict isn’t ours: below is what SCCS (EU Scientific Committee on Consumer Safety), ToxValDB (EPA Toxicity Value Database) said, verbatim.

What The Sources Say

SCCS (EU Scientific Committee on Consumer Safety)8
Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion on 2-Chloro-6-ethylamino-4-nitrophenol

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic Products

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion on Personal Use of Hair Dyes and Cancer Risk

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk

+3 more records.

ToxValDB (EPA Toxicity Value Database)2
Hazard claimView source →

EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Skin Sens. 1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claim

EPA ToxValDB genotoxicity: positive — positive reports: 3, negative: 1, Ames: positive, micronucleus: positive. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Scientific References

  • Assessment Strategies for Hair DyesSCCS — Scientific Committee on Consumer Safety
  • EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
  • EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
  • Memorandum on Hair Dye Substances and their Skin Sensitising PropertiesSCCS — Scientific Committee on Consumer Safety
  • Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004SCCS — Scientific Committee on Consumer Safety
  • Opinion on 2-Chloro-6-ethylamino-4-nitrophenolSCCS — Scientific Committee on Consumer Safety
  • Opinion on Personal Use of Hair Dyes and Cancer RiskSCCS — Scientific Committee on Consumer Safety
  • Opinion on the Use of Permanent Hair Dyes and Bladder Cancer RiskSCCS — Scientific Committee on Consumer Safety
  • PubChem — CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
  • Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic ProductsSCCS — Scientific Committee on Consumer Safety
  • ToxValDB — genotoxicityUS EPA — ToxValDB v97
  • ToxValDB — skin/eyeUS EPA — ToxValDB v97