1-Naphthol
- CAS
- 90-15-3
- EC
- 2019694
- PubChem CID
- 7005
- Molecular Formula
- C10H8O
- Molecular Weight
- 144.1700 g/mol
Creates color in hair dyes. May cause skin irritation and allergies; permitted in hair dyes at specific ratios.
What does it do?
A substance used to create color in hair dyes.
Details
A chemical used to create color in hair dyes. Because it can cause skin irritation and allergies, it is only permitted in specific concentrations in oxidative hair dyes. Its use is subject to strict regulations.
Hazards
Benefits
Functions
Restrictions
Where is it found?
Also known as
Function & Use
Hair Dyeing
Regulatory note
- EU 1223/2009 Annex IIIRestricted
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H302(98.1%)- Harmful if swallowed
- H311(31.8%)- Toxic in contact with skin
- H312(66.1%)- Harmful in contact with skin
- H314- Causes severe skin burns and eye damage
- H315(97.9%)- Causes skin irritation
- H317(25.0%)- May cause an allergic skin reaction
- H318(98.1%)- Causes serious eye damage
- H335(97.9%)- May cause respiratory irritation
- H371- May cause damage to organs
- H400(24.7%)- Very toxic to aquatic life
- H410(18.0%)- Very toxic to aquatic life with long lasting effects
- H411- Toxic to aquatic life with long lasting effects
- H412(23.6%)- Harmful to aquatic life with long lasting effects
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)9
EU 1223/2009 Annex III — SCCS opinion: Memorandum on Hair Dye Substances and their Skin Sensitising Properties
EU 1223/2009 Annex III — SCCS opinion: Opinion on 1-Naphthol
EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004
EU 1223/2009 Annex III — SCCS opinion: Opinion on Personal Use of Hair Dyes and Cancer Risk
EU 1223/2009 Annex III — SCCS opinion: Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk
+4 more records.
ToxValDB (EPA Toxicity Value Database)15
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Classification not possible. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Category 8.3A (Category 1). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Category 6.3A (Category 2). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: eye irritation: in vitro / ex vivo, classification: Corrosive or Irritation Persists for > 21 days, species: chicken, study: eye irritation, guideline: other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to, year: 2016. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (LLNA), classification: High Frequency of Sensitization, species: mouse, study: skin sensitization, guideline: according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay), year: 2003. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+10 more records.
EPA ToxCast (high-throughput in vitro screening)1
EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0.0232, antagonist=0). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.
Scientific References
- Assessment Strategies for Hair DyesSCCS — Scientific Committee on Consumer Safety
- EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EPA ToxCast/Tox21 — endocrine pathway screening (ER CERAPP, AR)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- Memorandum on Hair Dye Substances and their Skin Sensitising PropertiesSCCS — Scientific Committee on Consumer Safety
- Opinion concerning 1-NaphtholSCCS — Scientific Committee on Consumer Safety
- Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004SCCS — Scientific Committee on Consumer Safety
- Opinion on 1-NaphtholSCCS — Scientific Committee on Consumer Safety
- Opinion on Personal Use of Hair Dyes and Cancer RiskSCCS — Scientific Committee on Consumer Safety
- Opinion on the Use of Permanent Hair Dyes and Bladder Cancer RiskSCCS — Scientific Committee on Consumer Safety
- PubChem — CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
- ToxCast ER model — 1-Naphthol (DTXSID6021793)US EPA — ToxCast / CompTox
- ToxValDB — genotoxicityUS EPA — ToxValDB v97
- ToxValDB — skin/eyeUS EPA — ToxValDB v97
- Updated Recommended Strategy for Testing Hair Dyes for Their Potential Genotoxicity/Mutagenicity/CarcinogenicitySCCS — Scientific Committee on Consumer Safety
- Updated Recommended Strategy for Testing Oxidative Hair Dye Substances for their Potential Mutagenicity/GenotoxicitySCCS — Scientific Committee on Consumer Safety