ZINC OXIDE
- CAS
- 1314-13-2
- EC
- 2152225
- PubChem CID
- 3007857
- Molecular Formula
- OZn
- Molecular Weight
- 81.4000 g/mol
A full English write-up is not available yet. Category and regulatory notes above still apply.
Hazards
Benefits
Restrictions
Function & Use
Skin Protecting
Cosmetic Colorant
Bulking
UV Absorber
UV Filter
Regulatory note
- EU 1223/2009 Annex IVAllowed
- EU 1223/2009 Annex VIAllowed
Maximum concentration: 25%
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H333- H333
- H361- Suspected of damaging fertility or the unborn child
- H370- Causes damage to organs
- H400(100.0%)- Very toxic to aquatic life
- H410(100.0%)- Very toxic to aquatic life with long lasting effects
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)10
EU 1223/2009 Annex VI — SCCS opinion: Statement on Zinc Oxide used in Sunscreens
EU 1223/2009 Annex VI — SCCS opinion: Opinion on Safety of Nanomaterials in Cosmetic Products
EU 1223/2009 Annex VI — SCCS opinion: Clarification on Opinion SCCNFP/0932/05 on Zinc Oxide
EU 1223/2009 Annex VI — SCCS opinion: Addendum to the Opinion SCCS/1489/12 on Zinc oxide (nano form)
EU 1223/2009 Annex VI — SCCS opinion: Opinion concerning Zinc oxide
+5 more records.
Europe PMC (scientific literature)1
Cited by 69. Background The extensive biological applications of zinc oxide nanoparticles (ZnO NPs) in stomatology have created serious concerns about their biotoxicity. In our previous study, ZnO NPs were confirmed to transfer to the central nervous system (CNS) via the taste nerve pathway and cause neurodegeneration after 30 days of tongue instillation. However, the potential adverse effects on the brain cau
ToxValDB (EPA Toxicity Value Database)11
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Not classified. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Not classified. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Not classified. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin corrosion: in vitro / ex vivo, classification: Ambiguous, species: in vitro, reconstructed human skin model, study: skin irritation, guideline: OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test) according to, year: 2010. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: eye irritation: in vivo, classification: Moderate or Mild Irritation, species: rabbit, study: eye irritation, guideline: OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to, year: 1977. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+6 more records.
Scientific References
- Addendum to the Opinion SCCS/1489/12 on Zinc oxide (nano form)SCCS — Scientific Committee on Consumer Safety
- Clarification on Opinion SCCNFP/0932/05 on Zinc OxideSCCS — Scientific Committee on Consumer Safety
- EPA CompTox Chemicals Dashboard - DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng - Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca2+-dependent NF-κB and MAPK pathways.Particle and fibre toxicology
- OpenFDA Cosmetic Adverse Events (api.fda.gov/cosmetic/event)US FDA — unvalidated adverse event reports
- Opinion concerning Zinc oxideSCCS — Scientific Committee on Consumer Safety
- Opinion on Safety of Nanomaterials in Cosmetic ProductsSCCS — Scientific Committee on Consumer Safety
- Statement on Zinc Oxide used in SunscreensSCCS — Scientific Committee on Consumer Safety
- ToxValDB - genotoxicityUS EPA — ToxValDB v97
- ToxValDB - skin/eyeUS EPA — ToxValDB v97