Terpinolene
- CAS
- 586-62-9
- EC
- 2095780
- PubChem CID
- 11463
- Molecular Formula
- C10H16
- Molecular Weight
- 136.2300 g/mol
Fragrance agent. Use is restricted as it may irritate the skin.
What does it do?
Imparts a fresh and herbal scent to products.
Details
Naturally found in the essential oils of some plants, this substance is used in cosmetics to provide a fresh and herbal scent. Its use is restricted because it can irritate the skin. Although its allergen potential is low, it may cause reactions in sensitive skin.
Hazards
Benefits
Functions
Restrictions
Where is it found?
Also known as
Function & Use
Perfuming
Regulatory note
- EU 1223/2009 Annex IIIRestricted
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H226(100.0%)- Flammable liquid and vapour
- H227- Combustible liquid
- H304(100.0%)- May be fatal if swallowed and enters airways
- H315(59.3%)- Causes skin irritation
- H317(76.9%)- May cause an allergic skin reaction
- H400(18.6%)- Very toxic to aquatic life
- H410(18.7%)- Very toxic to aquatic life with long lasting effects
- H411(100.0%)- Toxic to aquatic life with long lasting effects
What The Sources Say
ToxValDB (EPA Toxicity Value Database)6
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Classification not possible. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Not classified. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Classification not possible. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: eye irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: eye irritation, guideline: OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to, year: 2000. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (LLNA), classification: High Frequency of Sensitization, species: mouse, study: skin sensitization, guideline: according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay), year: 2012. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+1 more records.
EPA ToxCast (high-throughput in vitro screening)1
EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0.00827, antagonist=0). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.
Scientific References
- EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- PubChem — CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
- ToxCast ER model — Terpinolene (DTXSID0027222)US EPA — ToxCast / CompTox
- ToxValDB — genotoxicityUS EPA — ToxValDB v97
- ToxValDB — skin/eyeUS EPA — ToxValDB v97