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RESORCINOL

Irritant0 products
CAS
108-46-3
EC
2035852
PubChem CID
5054
Molecular Formula
C6H6O2
Molecular Weight
110.1100 g/mol

A full English write-up is not available yet. Category and regulatory notes above still apply.

Hazards

Irritantⓘ

Benefits

Antibacterial

Functions

Colorant
Abrasive Agent

Restrictions

None Specified

Function & Use

Masking

Hair Dyeing

Regulatory note

  • EU 1223/2009 Annex IIIRestricted

Industry GHS notices (PubChem)

These are industry self-reports to ECHA, not our regulatory assessment.

  • H302- Harmful if swallowed
  • H313- H313
  • H315- Causes skin irritation
  • H317(15.2%)- May cause an allergic skin reaction
  • H318- Causes serious eye damage
  • H319(90.6%)- Causes serious eye irritation
  • H333- H333
  • H370(15.1%)- Causes damage to organs
  • H371(11.2%)- May cause damage to organs
  • H400(99.9%)- Very toxic to aquatic life
  • H410- Very toxic to aquatic life with long lasting effects
PubChem CID 5054 →
The verdict isn’t ours: below is what ToxValDB (EPA Toxicity Value Database), SCCS (EU Scientific Committee on Consumer Safety), EPA ToxCast (high-throughput in vitro screening), IARC (International Agency for Research on Cancer) said, verbatim.

What The Sources Say

SCCS (EU Scientific Committee on Consumer Safety)4
Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Opinion on Resorcinol

Safety assessment

EU 1223/2009 Annex III — SCCS opinion: Memorandum on Hair Dye Substances and their Skin Sensitising Properties

+2 more records.

IARC (International Agency for Research on Cancer)1
General assessmentView source →

IARC Group 3 - Not classifiable as to carcinogenicity. The available evidence is insufficient for a classification. This does NOT mean 'safe'; it means 'not enough data'. (Monograph volume: 15, Sup 7, 71). Caveat: IARC classifies HAZARD, not RISK - it says 'can cause cancer under some conditions', not 'causes cancer at cosmetic use levels'. Route and dose must be assessed separately. Data is a 01/2021 snapshot.

ToxValDB (EPA Toxicity Value Database)15
Hazard claimView source →

EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Category 1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claimView source →

EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Category 8.3A (Category 1). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claimView source →

EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Category 6.3A (Category 2). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claimView source →

EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (LLNA), classification: High Frequency of Sensitization, species: mouse, study: skin sensitization, guideline: according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) 0 (A00), 1, 5, 10, 25 and 50% w/v resorcinol, year: 2007. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

Hazard claimView source →

EPA ToxValDB skin/eye data — endpoint: eye irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: eye irritation, guideline: OECD Guideline 405 (Acute Eye Irritation / Corrosion) Concentration: 2.5 % according to, year: 2006. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

+10 more records.

EPA ToxCast (high-throughput in vitro screening)1
Safety assessmentView source →

EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0.00321, antagonist=0.0101). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.

Scientific References