Iodopropynyl butylcarbamate
- CAS
- 55406-53-6
- EC
- 2596275
- PubChem CID
- 62097
- Molecular Formula
- C8H12INO2
- Molecular Weight
- 281.0900 g/mol
A strong allergen; may cause itching and redness on the skin. Therefore, its use is strictly limited.
What does it do?
A preservative substance that protects the product by preventing bacteria and fungi
Details
A substance that protects the product by preventing the growth of bacteria and fungi. However, as it is a strong allergen, it may cause itching and redness on the skin. For this reason, its use is subject to very strict limits; it is permitted in low rates such as 0.02% in rinse-off products and 0.01% in leave-on products.
Benefits
Functions
Restrictions
Where is it found?
Also known as
Function & Use
Preservative
Regulatory note
- EU 1223/2009 Annex VAllowed
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H302(81.1%)- Harmful if swallowed
- H315(13.3%)- Causes skin irritation
- H317(57.3%)- May cause an allergic skin reaction
- H318(94.3%)- Causes serious eye damage
- H331(32.3%)- Toxic if inhaled
- H332(60.8%)- Harmful if inhaled
- H335(32.2%)- May cause respiratory irritation
- H372(28.7%)- Causes damage to organs through prolonged or repeated exposure
- H400(96.6%)- Very toxic to aquatic life
- H410(38.9%)- Very toxic to aquatic life with long lasting effects
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)2
EU 1223/2009 Annex V — SCCS opinion: Opinion on Iodopropynyl Butylcarbamate
EU 1223/2009 Annex V — SCCS opinion: Opinion on 3-Iodo-2-propynylbutylcarbamate (IBPC)
ToxValDB (EPA Toxicity Value Database)15
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Eye damage - category 1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Skin irritation - category 2. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Skin sensitisation - category 1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Category 6.4A (Category 2A). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Category 6.3B (Category 3). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+10 more records.
EPA ToxCast (high-throughput in vitro screening)1
EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0, antagonist=0.0283). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.
Scientific References
- EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EPA ToxCast/Tox21 — endocrine pathway screening (ER CERAPP, AR)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- OpenFDA Cosmetic Adverse Events (api.fda.gov/cosmetic/event)US FDA — unvalidated adverse event reports
- Opinion on 3-Iodo-2-propynylbutylcarbamate (IBPC)SCCS — Scientific Committee on Consumer Safety
- Opinion on Iodopropynyl ButylcarbamateSCCS — Scientific Committee on Consumer Safety
- PubChem — CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
- ToxCast ER model — 3-Iodo-2-propynyl-N-butylcarbamate (DTXSID0028038)US EPA — ToxCast / CompTox
- ToxValDB — cancerUS EPA — ToxValDB v97
- ToxValDB — genotoxicityUS EPA — ToxValDB v97
- ToxValDB — skin/eyeUS EPA — ToxValDB v97