HOMOSALATE

EU 1223/2009 Annex VI — SCCS opinion: OPINION on Homosalate

EU 1223/2009 Annex VI — SCCS opinion: Scientific Advice on the safety of Homosalate (CAS No 118-56-9

EU 1223/2009 Annex VI — SCCS opinion: EC No 204-260-8) as a UV-filter in cosmetic products

EPA ToxValDB skin/eye data — endpoint: skin corrosion: in vitro / ex vivo, classification: Studies Indicate No Significant Irritation, species: seeded human epidermal keratinocytes, study: skin irritation, guideline: EU Method B.46 (In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test) according to OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method) according to, year: 2012. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (non-LLNA), classification: Ambiguous, species: mouse, study: skin sensitization, guideline: according to other guideline: mouse ear swelling test, year: 1990. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (non-LLNA), classification: Not likely to be sensitizing, species: guinea pig, study: skin sensitization, guideline: equivalent or similar to OECD Guideline 406 (Skin Sensitisation), year: 1989. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0.0217, antagonist=0). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.