Eugenol
- CAS
- 97-53-0
- EC
- 2025891
- PubChem CID
- 3314
- Molecular Formula
- C10H12O2
- Molecular Weight
- 164.2000 g/mol
A component that provides a clove scent. Allergen; may lead to itching and redness in sensitive skin.
What does it do?
A fragrance component that provides a clove-like scent.
Details
Eugenol is a component naturally found in clove oil; it gives the product a spicy, clove-like scent. Allergen; may lead to itching, redness, and eczema-like reactions in sensitive skin. Therefore, it is mandatory to list its name on the label when used above a certain amount in cosmetic products.
Hazards
Benefits
Functions
Restrictions
Where is it found?
Function & Use
Perfuming
Tonic
Denaturant
Usage Restrictions
- Maximum Concentration - 3%
Distributed for Comment Only -- Do Not Cite or Quote
Regulatory note
- EU 1223/2009 Annex IIIRestricted
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H302(17.3%)- Harmful if swallowed
- H315(20.6%)- Causes skin irritation
- H317(99.8%)- May cause an allergic skin reaction
- H319(80.4%)- Causes serious eye irritation
- H336- May cause drowsiness or dizziness
- H351- Suspected of causing cancer
- H401- Toxic to aquatic life
- H412- Harmful to aquatic life with long lasting effects
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)4
EU 1223/2009 Annex III — SCCS opinion: Memorandum on the SCCNFP Opinion concerning Fragrance Allergy
EU 1223/2009 Annex III — SCCS opinion: Opinion concerning the Interim Position on Fragrance Allergy
EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Essential Oils
EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Fragrance Allergy in Consumers - A Review of the Problem - Analysis of the need for appropriate Consumer Information and Identification of Consumer Allergens
IARC (International Agency for Research on Cancer)1
IARC Group 3 - Not classifiable as to carcinogenicity. The available evidence is insufficient for a classification. This does NOT mean 'safe'; it means 'not enough data'. (Monograph volume: 36, Sup 7). Caveat: IARC classifies HAZARD, not RISK - it says 'can cause cancer under some conditions', not 'causes cancer at cosmetic use levels'. Route and dose must be assessed separately. Data is a 01/2021 snapshot.
ToxValDB (EPA Toxicity Value Database)15
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Category 6.4A (Category 2A). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Category 6.3A (Category 2). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Category 6.5B (Category 1). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (LLNA), classification: Low to Moderate Frequency of Sensitization, species: mouse, study: skin sensitization, guideline: according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay), year: 2006. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (non-LLNA), classification: Low to Moderate Frequency of Sensitization, species: guinea pig, study: skin sensitization, guideline: equivalent or similar to OECD Guideline 406 (Skin Sensitisation), year: 2004. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+10 more records.
EPA ToxCast (high-throughput in vitro screening)1
EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0, antagonist=0). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.
Scientific References
- CIR - Safety Assessment ofCosmetic Ingredient Review (CIR), Personal Care Products Council(2018)
- EPA CompTox Chemicals Dashboard - DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng - Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- IARC Monographs - Eugenol (Group 3 - Not classifiable as to carcinogenicity)IARC — WHO Uluslararası Kanser Araştırmaları Ajansı
- Memorandum on the SCCNFP Opinion concerning Fragrance AllergySCCS — Scientific Committee on Consumer Safety
- OpenFDA Cosmetic Adverse Events (api.fda.gov/cosmetic/event)US FDA — unvalidated adverse event reports
- Opinion concerning Essential OilsSCCS — Scientific Committee on Consumer Safety
- Opinion concerning Fragrance Allergy in Consumers - A Review of the Problem - Analysis of the need for appropriate Consumer Information and Identification of Consumer AllergensSCCS — Scientific Committee on Consumer Safety
- Opinion concerning the Interim Position on Fragrance AllergySCCS — Scientific Committee on Consumer Safety
- PubChem - CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
- ToxCast ER model - Eugenol (DTXSID9020617)US EPA — ToxCast / CompTox
- ToxValDB - cancerUS EPA — ToxValDB v97
- ToxValDB - genotoxicityUS EPA — ToxValDB v97
- ToxValDB - skin/eyeUS EPA — ToxValDB v97