DEHYDROACETIC ACID

Structure and Preparation Sodium Dehydroacetate is the sodium salt of the cyclic ketone Dehydroace- tic Acid. Dehydroacetic Acid conforms to the following structural formula(2): C-CH3 II OH 0 Dehydroacetic Acid Dehydroacetic Acid can be prepared by the action of N-bromosuccinimide on ketene dimer and by strong heating of acetoacetic ester.(3.4) Description and Properties Sodium Dehydroacetate occurs as a tasteless, odorless, white powder. It is soluble in water, propylene glycol, glycerin, and methanol but insoluble in most organic soIvents.(3*5) Dehydroacetic Acid is a white to cream crystalline powder with practically no odor or taste. Although only slightly soluble in water, Dehydroacetic Acid dis- solves in aqueous solutions of fixed alkalies, acetone, benzene, ether, and meth- anol.(5*6) Table 1 summarizes the physicochemical properties of Dehydroacetic Acid and its sodium salt. Reactivity/Stability Dehydroacetic Acid is a reactive, unstable, and combustible compound.(3s7’ Profoundly affected by pH, the acid is active only in its undissociated state; 65 percent is undissociated at pH 5 in comparison to 6 to 7 percent at pH 6.5. The degree of effectiveness of Dehydroacetic Acid and Sodium Dehydroacetate against various bacteria and fungi is greatest in acidic media.(‘+“) The minimum inhibitory concentration (MIC) of Dehydroacetic Acid against Escherichia co/i … [kırpıldı — bölüm toplam 131941 karakter]

EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Classification not possible. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Classification not possible. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: skin irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: skin irritation, guideline: OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 28 Jul 2015 equivalent or similar to, year: 1974. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: eye irritation: in vitro / ex vivo, classification: Studies Indicate No Significant Irritation, species: chicken, study: eye irritation, guideline: other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) 26 Jul 2013 according to EU method B.48 (Isolated chicken eye test method for identifying occular corrosives and severe irritants) according to, year: 2016. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (LLNA), classification: Not likely to be sensitizing, species: mouse, study: skin sensitization, guideline: according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) 23 Jul 2010, year: 2008. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0, antagonist=0). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.