Chlorphenesin

Definition and Structure As given in the International Cosmetic Ingredient Dictionary and Handbook, chlorphenesin (CAS No. 104-29-0) is a chlorophenol derivative defined as the organic compound that conforms to the formula shown in Figure 1.:1 Figure1. Chlorphenesin Other names for this chemical include: 3-(4-Chlorophenoxy)-1,2-Propanediol; 1,2-Propanediol,3-(4-Chlorophenoxy)-; and p-Chlorophenyl Glyceryl Ether.1 Chemical and Physical Properties A UV spectral analysis of 0.01% aqueous chlorphenesin solution indicated maximum absorption at 279 nm.2 Additional properties of chlorphenesin are found in Table 1. Methods of Production Chlorphenesin is prepared by condensing equimolar amounts of p-chlorophenol and glycidol in the presence of a tertiary amine or a quaternary ammonium salt as a catalyst.3 1 CIR Panel Book Page 18  Distributed for Comment Only -- Do Not Cite or Quote USE Cosmetic Chlorphenesin reportedly functions as a biocide in cosmetic products.4 Reportedly, chlorphenesin (ELESTAB® CPN; concentration of use = 0.10 to 0.30%) has bactericidal activity against Gram (+) and Gram (-) bacteria, fungicidal activity against Aspergillus niger IMI 149007 and Penicillium pinophilum IMI 87160 (fungi), and is also active against Candida albicans NCPF 3179 and Saccharomyces cerevisiae NCPF 3275 (yeasts).5 According to information supplied to the Food and Drug Administration (FDA) by industry as part of the Voluntary … [kırpıldı — bölüm toplam 40181 karakter]

CIR tentative (n.d.): The CIR Expert Panel concluded that chlorphenesin is safe in the present practices of use and concentration described in this safety assessment.

Cited by 1.

EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Category 6.4A (Category 2A). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Category 6.3A (Category 2). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (LLNA), classification: Not likely to be sensitizing, species: mouse, study: skin sensitization, guideline: according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) November, 2000, year: 2003. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: eye irritation: in vitro / ex vivo, classification: Ambiguous, species: cattle, study: eye irritation, guideline: other guideline: OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) 2013 according to, year: 2014. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.

EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: SkinSens1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.