Butylphenyl Methylpropional
- CAS
- 80-54-6
- EC
- 2012898
- PubChem CID
- 228987
- Molecular Formula
- C14H20O
- Molecular Weight
- 204.3100 g/mol
A fragrance component providing a jasmine scent. Banned in cosmetics in the EU as it may harm reproductive health.
What does it do?
An old fragrance component providing a jasmine-like scent, now banned in cosmetic products in the EU.
Details
Butylphenyl Methylpropional was a component formerly used frequently in perfumes to provide a jasmine-like scent. However, it has been banned in cosmetic products in the European Union because it was found to potentially harm reproductive health (CMR class). It is no longer found in new products, though it may still appear in older ones.
Hazards
Benefits
Functions
Restrictions
Where is it found?
Function & Use
Perfuming
Usage Restrictions
- Maximum Concentration - 3%
Distributed for Comment Only -- Do Not Cite or Quote
Regulatory note
- EU 1223/2009 Annex IIProhibited
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H227- Combustible liquid
- H302(98.7%)- Harmful if swallowed
- H315(90.9%)- Causes skin irritation
- H317(99.6%)- May cause an allergic skin reaction
- H320- Causes eye irritation
- H335- May cause respiratory irritation
- H336- May cause drowsiness or dizziness
- H360- May damage fertility or the unborn child
- H361(84.9%)- Suspected of damaging fertility or the unborn child
- H411(84.2%)- Toxic to aquatic life with long lasting effects
- H412(14.0%)- Harmful to aquatic life with long lasting effects
What The Sources Say
ToxValDB (EPA Toxicity Value Database)8
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Not classified. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Category 2. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Category 1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Category 6.3B (Category 3). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: Category 6.5B (Category 1). Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+3 more records.
EPA ToxCast (high-throughput in vitro screening)1
EPA ToxCast ER model: NO estrogen receptor activity found (AUC agonist=0.0022, antagonist=0). Tested in 18 in vitro assays. Caveat: this is an in vitro screening model with no dose or exposure context; it does NOT mean an effect occurs in humans at cosmetic use levels.
Scientific References
- CIR — Safety Assessment ofCosmetic Ingredient Review (CIR), Personal Care Products Council(2018)
- EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- OpenFDA Cosmetic Adverse Events (api.fda.gov/cosmetic/event)US FDA — unvalidated adverse event reports
- ToxCast ER model — 2-(4-Tert-Butylbenzyl)propionaldehyde (DTXSID9026500)US EPA — ToxCast / CompTox
- ToxValDB — genotoxicityUS EPA — ToxValDB v97
- ToxValDB — skin/eyeUS EPA — ToxValDB v97