Beta-Caryophyllene
- CAS
- 87-44-5
- EC
- 2017461
- PubChem CID
- 5281515
- Molecular Formula
- C15H24
- Molecular Weight
- 204.3500 g/mol
A plant-derived fragrance ingredient. Natural and generally safe, though very rare allergy cases have been reported.
What does it do?
A plant-derived fragrance ingredient and flavoring agent.
Details
A natural terpenoid found in plants such as black pepper, cloves, and cannabis. It has a spicy, woody scent and is used in perfumes and aromatherapy. It is generally considered safe and is thought to have anti-inflammatory properties. However, in very rare cases, it may lead to skin allergies.
Hazards
Benefits
Functions
Restrictions
Where is it found?
Function & Use
Skin Conditioning
Perfuming
Masking
Regulatory note
- EU 1223/2009 Annex IIIRestricted
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H304(99.5%)- May be fatal if swallowed and enters airways
- H317(78.9%)- May cause an allergic skin reaction
What The Sources Say
ToxValDB (EPA Toxicity Value Database)5
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: SkinIrr2. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (non-LLNA), classification: Low to Moderate Frequency of Sensitization, species: guinea pig, study: skin sensitization, guideline: equivalent or similar to OECD Guideline 406 (Skin Sensitisation), year: 2006. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: skin sensitisation: in vivo (LLNA), classification: Low to Moderate Frequency of Sensitization, species: mouse, study: skin sensitization, guideline: equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay), year: 2006. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: eye irritation: in vivo, classification: Studies Indicate No Significant Irritation, species: rabbit, study: eye irritation, guideline: OECD Guideline 405 (Acute Eye Irritation / Corrosion) 1987 according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) 1997 according to, year: 2000. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+1 more records.
Scientific References
- EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- OpenFDA Cosmetic Adverse Events (api.fda.gov/cosmetic/event)US FDA — unvalidated adverse event reports
- ToxValDB — genotoxicityUS EPA — ToxValDB v97
- ToxValDB — skin/eyeUS EPA — ToxValDB v97