4-AMINO-2-HYDROXYTOLUENE
- CAS
- 2835-95-2
- EC
- 2206186
- PubChem CID
- 17818
- Molecular Formula
- C7H9NO
- Molecular Weight
- 123.1500 g/mol
A full English write-up is not available yet. Category and regulatory notes above still apply.
Hazards
Benefits
Functions
Restrictions
Function & Use
Hair Dyeing
Regulatory note
- EU 1223/2009 Annex IIIRestricted
Industry GHS notices (PubChem)
These are industry self-reports to ECHA, not our regulatory assessment.
- H315(68.2%)- Causes skin irritation
- H317(72.6%)- May cause an allergic skin reaction
- H319(74.9%)- Causes serious eye irritation
- H320- Causes eye irritation
- H335(74.3%)- May cause respiratory irritation
- H400(38.0%)- Very toxic to aquatic life
- H410(37.4%)- Very toxic to aquatic life with long lasting effects
- H411(26.3%)- Toxic to aquatic life with long lasting effects
What The Sources Say
SCCS (EU Scientific Committee on Consumer Safety)7
EU 1223/2009 Annex III — SCCS opinion: Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic Products
EU 1223/2009 Annex III — SCCS opinion: Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004
EU 1223/2009 Annex III — SCCS opinion: Opinion on Personal Use of Hair Dyes and Cancer Risk
EU 1223/2009 Annex III — SCCS opinion: Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk
EU 1223/2009 Annex III — SCCS opinion: Assessment Strategies for Hair Dyes
+2 more records.
Europe PMC (scientific literature)1
Cited by 7. Hair dye components such as pyrogallol and cresol have been shown previously to promote allergic reactions such as rashes, dermal inflammation, irritation and dermatitis. The objective of this study was to determine the contact sensitization potential of pyrogallol (PYR) and 5-amino-o-cresol (AOC) when applied dermally to female BALB/c mice. Measurement of the contact hypersensitivity response was
ToxValDB (EPA Toxicity Value Database)5
EPA ToxValDB skin/eye data — endpoint: Skin Sensitization, classification: SkinSens1. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Eye Irritation, classification: Category 2B. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
EPA ToxValDB skin/eye data — endpoint: Skin Irritation, classification: Classification not possible. Caveat: this is an aggregated record; dose, species and route of exposure must be considered together.
+2 more records.
Scientific References
- Assessment Strategies for Hair DyesSCCS — Scientific Committee on Consumer Safety
- Contact sensitizing potential of pyrogallol and 5-amino-o-cresol in female BALB/c mice.Toxicology
- EPA CompTox Chemicals Dashboard — DSSTox identifiers mapped to CAS (2021r1)US EPA, Center for Computational Toxicology and Exposure
- EU CosIng — Cosmetic Ingredient Database full exportEuropean Commission, DG GROW
- Memorandum on Hair Dye Substances and their Skin Sensitising PropertiesSCCS — Scientific Committee on Consumer Safety
- Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004SCCS — Scientific Committee on Consumer Safety
- Opinion on 4-Amino-2-hydroxytolueneSCCS — Scientific Committee on Consumer Safety
- Opinion on Personal Use of Hair Dyes and Cancer RiskSCCS — Scientific Committee on Consumer Safety
- Opinion on the Use of Permanent Hair Dyes and Bladder Cancer RiskSCCS — Scientific Committee on Consumer Safety
- PubChem — CID-Synonym-filtered bulk + PUG REST propertiesNCBI / National Library of Medicine
- Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic ProductsSCCS — Scientific Committee on Consumer Safety
- ToxValDB — genotoxicityUS EPA — ToxValDB v97
- ToxValDB — skin/eyeUS EPA — ToxValDB v97